Sinclair Method Studies
Published on: 11/06/2025
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Naltrexone and The Sinclair Method in the UK and Ireland: Why Support Is Essential for Success
Bruce Rose Published on: 06/06/2025
A science-based approach called The Sinclair Method (TSM) is gaining visibility in the UK and Ireland. At its core is Naltrexone, a medication that rewires the brain’s response to alcohol.
The Sinclair Method (TSM)
Is Alcohol Recovery Changing the Model? A New Era with the Sinclair Method
Bruce Rose Published on: 04/06/2025
The landscape of alcohol recovery is undergoing a major transformation. For decades, abstinence was seen as the only viable path to recovery—often rigid, binary, and stigmatised. But science and innovation are rewriting that narrative. Today, we stand at the threshold of a new paradigm—one rooted in neuroscience, evidence, and personal empowerment.
The Sinclair Method (TSM)
Is Naltrexone Available in the UK and Ireland? What You Need to Know
Bruce Rose Published on: 28/05/2025
Naltrexone is a non-addictive opioid antagonist that blocks the brain’s ability to feel pleasure from alcohol. Over time, drinking becomes less rewarding, reducing cravings and consumption naturally — a process known as Pharmacological Extinction. This effect is the foundation of The Sinclair Method (TSM), where individuals take Naltrexone only prior to drinking, gradually reprogramming their brain’s response to alcohol.
The Sinclair Method (TSM)
Who Are Rethink Drink? Changing the Face of Alcohol Recovery in the UK
Bruce Rose Published on: 23/05/2025
Founded by Matt Brindley and Bruce Rose, Rethink Drink champions an evidence-based, client-centred approach known as The Sinclair Method (TSM). They’re not just another recovery service—they’re redefining what it means to take back control.
The Sinclair Method (TSM)
